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Codeine has actually been described to point out no evidence of carcinogenicity or mutagenicity in a number of take a look at systems, including the micronucleus and sperm abnormality assays as well as Salmonella assay. Promethazine was nonmutagenic from the Salmonella take a look at system of Ames.benzhydrocodone/acetaminophen and codeine the two

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